Sebaceous Carcinoma of the Breast: Fact or Fiction? A Case Report and a Review of the Literature
| Autor: | Anna Maria Dalena, Maria Paola Mariani, Ludovica De Vincentiis, Gerardo Ferrara, Anna Maria Cesinaro |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Biopsy Fine-Needle Breast Neoplasms World health Pathology and Forensic Medicine Sebaceous Glands Fine needle aspiration cytology Sebaceous Differentiation Carcinoma medicine Humans Breast Sebaceous Gland Neoplasms Mastectomy business.industry Carcinoma Ductal Breast Middle Aged medicine.disease Immunohistochemistry Surgery Female Anatomy Breast carcinoma business Positive staining Sebaceous carcinoma |
| Zdroj: | International journal of surgical pathology. 29(2) |
| ISSN: | 1940-2465 |
| Popis: | Introduction. Previously considered an exceedingly rare entity, sebaceous carcinoma of the breast is now regarded in the World Health Organization 2019 classification as a “special histopathological pattern” of invasive breast carcinoma of no special type. Case Description. In this article, we report the case of a fine needle aspiration cytology and the histopathological features of a breast carcinoma with clear-cut morphological features suggesting sebaceous differentiation, but showing no positive staining with the anti-adipophilin antibody. Conclusions. A morphologically clear-cut sebaceous differentiation is not invariably associated with adipophilin positivity; moreover, in breast carcinoma, adipophilin positivity does not automatically imply sebaceous differentiation. At present, immunomorphological evidence for the recognition of sebaceous carcinoma as a “special type” breast carcinoma subtype is too weak. |
| Databáze: | OpenAIRE |
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