Coronary artery disease screening in type II diabetic patients: Prognostic value of rest and stress echocardiography
| Autor: | Matteo Monami, Vanessa Boni, Francesca Innocenti, Francesca Bartalucci, Sonia Vicidomini, Edoardo Mannucci, Riccardo Pini |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Dobutamine stress echocardiography Endocrinology Diabetes and Metabolism Myocardial Ischemia Coronary Artery Disease Disease-Free Survival Coronary artery disease Internal medicine Diabetes mellitus Internal Medicine medicine Stress Echocardiography Humans Wall motion Good outcome Rest (music) Retrospective Studies business.industry General Medicine Prognosis medicine.disease Diabetes Mellitus Type 2 Cardiology Regression Analysis Inducible ischemia business Echocardiography Stress Glomerular Filtration Rate |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 8:18-23 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2013.10.010 |
| Popis: | Presence of inducible ischemia in type II diabetic patients is associated with an adverse outcome, but less is known about prognostic value of resting wall motion abnormalities (WMA).From October 2006 to May 2008, 278 patients underwent to CAD screening, according to ADA criteria, by dobutamine stress echocardiography (DSE). Between July and September 2009, all patients were contacted to verify the occurrence of new cardiac events.Resting-WMA were present in 63 patients; 88 subjects showed inducible ischemia. During the follow-up, we observed 24 new cardiac events; patients with a good outcome showed less frequently resting WMA (19 vs 50%). Inducible ischemia (71% vs 28%; p0.001) and a more extensive area of inducible ischemia, expressed by a higher value of peak WMSI (1.63±0.45 vs 1.17±0.31; p0.0001), were more frequent in patients with adverse outcome. A Cox regression analysis showed that only a higher peak WMSI (HR 6.645, 95% CI 2.782-15.874, p0.0001) was associated with a bad outcome. Event-free survival was lower in presence of rest WMA (79% vs 94%, p0.0001) and a higher peak WMSI (66% vs 95%, p0.0001).In diabetic patients presence of an extensive inducible ischemia was independently associated with a worst outcome; resting WMA were associated with reduced event-free survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect