| Autor: |
Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu, Jiayin Ye, Jianchang Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xinhua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Advanced science (Weinheim, Baden-Wurttemberg, Germany). |
| ISSN: |
2198-3844 |
| Popis: |
Niche for stem cells profoundly influences their maintenance and fate during tissue homeostasis and pathological disorders; however, the underlying mechanisms and tissue-specific features remain poorly understood. Here, it is reported that fatty acid desaturation catabolized by stearoyl-coenzyme A desaturase 1 (SCD1) regulates hair follicle stem cells (HFSCs) and hair growth by maintaining the bulge, niche for HFSCs. Scd1 deletion in mice results in abnormal hair growth, an effect exerted directly on keratin K14 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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