Can Diffusion-Weighted Imaging and Related Apparent Diffusion Coefficient be a Prognostic Value in Women With Breast Cancer?

Autor:	Rocchina Caivano, Giuseppina Dinardo, Luca Macarini, Matilde Gioioso, Giuseppe Guglielmi, Giancarlo Iannelli, Vittorio Simeon, Antonella Lotumolo, Aldo Cammarota, Antonio Villonio, Alexis Zandolino, Paola Rabasco, Felice D'Antuono
Přispěvatelé:	Rabasco, Paola, Caivano, Rocchina, Simeon, Vittorio, Dinardo, Giuseppina, Lotumolo, Antonella, Gioioso, Matilde, Villonio, Antonio, Iannelli, Giancarlo, D'Antuono, Felice, Zandolino, Alexi, Macarini, Luca, Guglielmi, Giuseppe, Cammarota, Aldo
Rok vydání:	2017
Předmět:	Oncology Cancer Research medicine.medical_specialty diffusion-weighted imaging Breast Neoplasms 030218 nuclear medicine & medical imaging Metastasis 03 medical and health sciences Breast cancer 0302 clinical medicine Predictive Value of Tests Internal medicine Progesterone receptor medicine magnetic resonance imaging Humans Cutoff Effective diffusion coefficient Lymph node Aged Retrospective Studies medicine.diagnostic_test business.industry Carcinoma Ductal Breast prognostic factors Magnetic resonance imaging General Medicine Middle Aged Prognosis medicine.disease body regions Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis apparent diffusion coefficient Female business Diffusion MRI
Zdroj:	Cancer Investigation. 35:92-99
ISSN:	1532-4192 0735-7907
DOI:	10.1080/07357907.2016.1267740
Popis:	Purpose: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer. Materials and methods: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3years were enrolled. On DWI, we obtained the ADC values, and these were correlated with the clinical condition of patients at 3years. Moreover, tumour size, lymph node status, and molecular markers, including estrogens receptor, progesterone receptor, Ki-67 index, and human growth factor receptor 2 protein, were correlated with ADC values. This study was approved by the Scientific Committee of our institution. Results: We considered patients with metastasis at 3years (12 patients - 20%) and without metastasis (48 patients - 80%). The mean ADC value in patients with no metastases at 3years was 1.06 +/- 0.38, while for patients with metastases it was 0.74 +/- 0.34 (p = .011). The receiver-operator curve analysis identified a value of 0.75 (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574fc2426a96c2f5118f0fef366e377e https://doi.org/10.1080/07357907.2016.1267740 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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