Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks
| Autor: | Benjamin Acland, Leah Czerniewski, Anish Mitra, Marcus E. Raichle, Ryan V. Raut, Jin-Moo Lee, Ping Yan, Abraham Z. Snyder, Lawrence H. Snyder, Andrew W. Kraft, Joseph P. Culver, Zachary P. Rosenthal, Deima Koko, Adam Q. Bauer |
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| Rok vydání: | 2020 |
| Předmět: |
Interneuron
Cognitive Neuroscience Local field potential Somatosensory system Mice Cellular and Molecular Neuroscience Interneurons Neural Pathways medicine Biological neural network Animals Neuronal Plasticity biology Pyramidal Cells Optical Imaging Neural Inhibition Signal Processing Computer-Assisted Somatosensory Cortex Electrophysiology Parvalbumins medicine.anatomical_structure Vibrissae GCaMP Cortical Excitability biology.protein GABAergic Electrocorticography Corrigendum Neuroscience Parvalbumin |
| Zdroj: | Cereb Cortex |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | Electrophysiological recordings have established that GABAergic interneurons regulate excitability, plasticity, and computational function within local neural circuits. Importantly, GABAergic inhibition is focally disrupted around sites of brain injury. However, it remains unclear whether focal imbalances in inhibition/excitation lead to widespread changes in brain activity. Here, we test the hypothesis that focal perturbations in excitability disrupt large-scale brain network dynamics. We used viral chemogenetics in mice to reversibly manipulate parvalbumin interneuron (PV-IN) activity levels in whisker barrel somatosensory cortex. We then assessed how this imbalance affects cortical network activity in awake mice using wide-field optical neuroimaging of pyramidal neuron GCaMP dynamics as well as local field potential recordings. We report 1) that local changes in excitability can cause remote, network-wide effects, 2) that these effects propagate differentially through intra- and interhemispheric connections, and 3) that chemogenetic constructs can induce plasticity in cortical excitability and functional connectivity. These findings may help to explain how focal activity changes following injury lead to widespread network dysfunction. |
| Databáze: | OpenAIRE |
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