Arterial and venous cytokine response to cardiopulmonary bypass for low risk CABG and relation to hemodynamics
| Autor: | Mario C. Deng, G. Assmann, M. Erren, M. Wiedner, H. H. Scheld, T. Mollhoff |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Time Factors Adolescent Interleukin-1beta Cardiac index Hemodynamics Veins law.invention Interferon-gamma Heart Rate Reference Values Risk Factors law Preoperative Care Heart rate Cardiopulmonary bypass Humans Medicine Pulmonary Wedge Pressure Coronary Artery Bypass Pulmonary wedge pressure Aged Postoperative Care Cardiopulmonary Bypass Ejection fraction Interleukin-6 Tumor Necrosis Factor-alpha business.industry Receptors Interleukin-2 Arteries General Medicine Middle Aged Coronary Vessels Peptide Fragments medicine.anatomical_structure Solubility Elective Surgical Procedures Anesthesia Vascular resistance Interleukin-2 Female Surgery Cardiology and Cardiovascular Medicine business Interleukin-1 Artery |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 9:22-29 |
| ISSN: | 1010-7940 |
| Popis: | During and after cardiopulmonary bypass (CPB), cytokines may affect cardiac performance and the immune response and are therefore of diagnostic and therapeutic interest. We have used EIA/EASIA kits to measure arterial and venous levels of interleukin-1-β (IL-1-β, IL-2, IL-2 receptor (IL-2-R), IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ in 12 men and 3 women (mean age 59.4±8.5 years, mean left ventricular ejection fraction 66±11%, average of 2.5±0.64 vessels affected by disease) undergoing elective coronary artery bypass grafting (CABG). On average each patient received 3±0.85 bypass grafts and required a postoperative maximum dopamine-dose of 3.8 μg/kg per min. Mean CPB and operation times were 60±21 min, and 132±16 min, respectively. During CPB, the venous levels of IL-2 temporarily decreased from 234 to 0 (p |
| Databáze: | OpenAIRE |
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