Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys
| Autor: | Jörn E. Schmitz, Peter J. Dailey, Wesley M. Taylor, Paul Racz, Meryl A. Forman, Christine E. Nickerson, Ronald S. Veazey, Marcelo J. Kuroda, Norman L. Letvin, Aruna Seth, Michelle A. Lifton, Klara Tenner-Racz |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
viruses
Immunology Population Simian Acquired Immunodeficiency Syndrome Epitopes T-Lymphocyte Gene Products gag Apoptosis Hepatitis Animal medicine.disease_cause Epitope Immunophenotyping Cell Movement T-Lymphocyte Subsets MHC class I medicine Immunology and Allergy Cytotoxic T cell Animals Lymphocyte Count L-Selectin education education.field_of_study biology Histocompatibility Antigens Class I T lymphocyte Simian immunodeficiency virus Virology Macaca mulatta CTL Liver biology.protein Simian Immunodeficiency Virus CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 164(11) |
| ISSN: | 0022-1767 |
| Popis: | The immunopathogenesis of AIDS-associated hepatitis was explored in the SIV/rhesus monkey model. The livers of SIV-infected monkeys showed a mild hepatitis, with a predominantly CD8+ T lymphocyte infiltration in the periportal fields and sinusoids. These liver-associated CD8+ T cells were comprised of a high percentage of SIV-specific CTL as defined by MHC class I/Gag peptide tetramer binding and Gag peptide epitope-specific lytic activity. There was insufficient viral replication in these livers to account for attracting this large number of functional virus-specific CTL to the liver. There was also no evidence that the predominant population of CTL were functionally end-stage cells trapped in the liver and destined to undergo apoptotic cell death in that organ. Interestingly, we noted that liver tetramer-binding cells showed an increased expression of CD62L, an adhesion molecule usually only rarely expressed on tetramer-binding cells. This observation suggests that the expression of specific adhesion molecules by CTL might facilitate the capture of these cells in the liver. These results demonstrate that functional SIV-specific CD8+ T cells are present in large numbers in the liver of chronically SIV-infected monkeys. Thus, the liver may be a trap for virus-specific cytotoxic T cells. |
| Databáze: | OpenAIRE |
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