Fruit and Vegetable Intake and Stomach Cancer among Male Adults: A Case-Control Study in Northern Viet Nam
| Autor: | Toshio Ogawa, Khanpaseuth Sengngam, Le Hong Phuoc, Tran Hieu Hoc, Nlandu Roger Ngatu, Dinh Thi Minh, Le Tran Ngoan, Pham Van Phu, Shunya Ikeda |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Stomach cancer Physiology Logistic regression Helicobacter Infections Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms Vegetables Tobacco Smoking medicine vegetable Humans General hospital Igg elisa Aged Helicobacter pylori biology business.industry Viet nam Case-control study fruit General Medicine Middle Aged Prognosis biology.organism_classification medicine.disease Diet 030104 developmental biology Vietnam Case-Control Studies 030220 oncology & carcinogenesis Fruit intake Female business Research Article Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2020.21.7.2109 |
| Popis: | Objective This study investigated the association between fruit and vegetable intake and stomach cancer, with considering the impacts of Helicobacter pylori (H. pylori) infection and tobacco smoking. Methods A case-control study featuring 80 male incident stomach-cancer cases and 146 male controls was conducted in a general hospital in Viet Nam. A semi-quantitative food frequency and demographic lifestyle questionnaire were used; and venous blood samples were collected to determine H. pylori status by IgG ELISA. The respective associations between fruit and vegetable intake and stomach cancer were examined using unconditional logistic regression analysis with adjustments for possible cofactors. Results Fruit intake and stomach cancer showed a weak inverse association when this became non-significant after adjusting for H. pylori infection (OR = 0.50, 95%CI: 0.22-1.12, p trend = 0.094). Stratifying by H. pylori status returned a negative trend for fruit intake and stomach cancer among H. pylori-negative participants (OR = 0.21, 95%CI: 0.06-0.69, p trend = 0.010), but no significant interaction for H. pylori-positive participants (OR = 0.76, 95%CI: 0.21-2.68, p trend = 0.670). Vegetable intake and stomach cancer showed no association, regardless of H. pylori status. Compared to ever-smokers with low intake, never-smokers with high vegetable (OR = 0.25, 95% CI: 0.06-0.95) and fruit intake (OR = 0.20, 95%CI: 0.06-0.65) showed the lowest odds of stomach cancer. Conclusions Fruit, but not vegetable, intake showed a weak inverse association with stomach cancer. H. pylori infection and tobacco-smoking status may influence the protective effects of fruit and vegetable intake on stomach cancer. . |
| Databáze: | OpenAIRE |
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