Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis : a prospective longitudinal inception cohort study

Autor: Guy Serre, Anders Lundquist, Karl Skriner, Johan Rönnelid, Antonia Boman, Ewa Berglin, Linda Mathsson-Alm, Monica Hansson, Mikael Brink, Solbritt Rantapää-Dahlqvist, Rikard Holmdahl, Lars Klareskog
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
musculoskeletal diseases
medicine.medical_specialty
28-joint disease activity score (DAS28)
Immunology
Rheumatoid Arthritis
Early rheumatoid arthritis
Anti-Citrullinated Protein Antibodies
Arthritis
Rheumatoid
Cohort Studies
Biological Factors
Epitopes
multiplex antibody analyses
Rheumatology
Adrenal Cortex Hormones
HLA Antigens
Rheumatoid Factor
immune system diseases
Internal medicine
Immunology and Allergy
Medicine
Humans
In patient
Prospective Studies
skin and connective tissue diseases
Aged
Autoantibodies
Rheumatology and Autoimmunity
Reumatologi och inflammation
biology
business.industry
Smoking
Protein Tyrosine Phosphatase
Non-Receptor Type 22
Middle Aged
INCEPTION COHORT
Radiography
anti-citrullinated protein/peptide antibodies (ACPA)
Treatment Outcome
Radiological weapon
Antirheumatic Agents
Larsen score
biology.protein
Disease Progression
Female
Antibody
business
Zdroj: RMD Open
Popis: IntroductionAnticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.MethodsThe ACPA reactivities were assessed in 1022 patients with early RA (symptoms ResultsFrequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope (HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase non-receptor type 22 (1858C/T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (pConclusionsSeveral ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression.
Databáze: OpenAIRE
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