Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis : a prospective longitudinal inception cohort study
Autor: | Guy Serre, Anders Lundquist, Karl Skriner, Johan Rönnelid, Antonia Boman, Ewa Berglin, Linda Mathsson-Alm, Monica Hansson, Mikael Brink, Solbritt Rantapää-Dahlqvist, Rikard Holmdahl, Lars Klareskog |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty 28-joint disease activity score (DAS28) Immunology Rheumatoid Arthritis Early rheumatoid arthritis Anti-Citrullinated Protein Antibodies Arthritis Rheumatoid Cohort Studies Biological Factors Epitopes multiplex antibody analyses Rheumatology Adrenal Cortex Hormones HLA Antigens Rheumatoid Factor immune system diseases Internal medicine Immunology and Allergy Medicine Humans In patient Prospective Studies skin and connective tissue diseases Aged Autoantibodies Rheumatology and Autoimmunity Reumatologi och inflammation biology business.industry Smoking Protein Tyrosine Phosphatase Non-Receptor Type 22 Middle Aged INCEPTION COHORT Radiography anti-citrullinated protein/peptide antibodies (ACPA) Treatment Outcome Radiological weapon Antirheumatic Agents Larsen score biology.protein Disease Progression Female Antibody business |
Zdroj: | RMD Open |
Popis: | IntroductionAnticitrullinated peptide antibody (ACPA) responses for 22 citrullinated peptides in patients with early rheumatoid arthritis (RA) were analysed and related to radiological and clinical outcome during the first 2 years in a prospective inception cohort.MethodsThe ACPA reactivities were assessed in 1022 patients with early RA (symptoms ResultsFrequency of ACPA reactivities varied between 13.3% and 63.1%. Of the anticyclic citrullinated peptide-2 (anti-CCP2) antibody-negative patients, ACPA reactivities were positive in 32.6%. Smoking, human leucocyte antigen-shared epitope (HLA-SE), anti-CCP2/rheumatoid factor, protein tyrosine phosphatase non-receptor type 22 (1858C/T) and DAS28 were significantly associated with number of ACPA reactivities. The ACPA reactivities modified differently the development of DAS28 over 24 months (identified using trajectories). Anti-Filaggrin307-324, anti-hnRNP (Peptide)-Z1 and anti-F4-CIT-R antibodies anticipated lower DAS28 values (pConclusionsSeveral ACPA reactivities modified significantly the DAS28 development during the first 24 months and were significantly associated with Larsen score at baseline, 24 months and radiological progression. |
Databáze: | OpenAIRE |
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