Apheresis techniques in lymphokine-activated killer cell production
| Autor: | Irena Sniecinski, Kim Margolin, Bonnie J. Mills, Kim Sentinella |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adoptive cell transfer Population chemical and pharmacologic phenomena Lymphocyte Activation Peripheral blood mononuclear cell Internal medicine medicine Cytotoxic T cell Humans Leukapheresis education Melanoma education.field_of_study Lymphokine-activated killer cell business.industry Rectal Neoplasms Immunization Passive Cancer Hematology General Medicine Middle Aged medicine.disease Kidney Neoplasms Recombinant Proteins Killer Cells Natural Regimen Apheresis Immunology Colonic Neoplasms Blood Component Removal Leukocytes Mononuclear Interleukin-2 Female business |
| Zdroj: | Journal of clinical apheresis. 4(2-3) |
| ISSN: | 0733-2459 |
| Popis: | Adoptive transfer of autologous lymphokine-activated killer cells (LAK) in conjunction with recombinant interleu-kin-2 (rIL-2) has been reported to produce significant regression in metastatic disease in patients with advanced cancer. In an effort to confirm the results reported by the Surgery Branch of the National Cancer Institute, the same IL-2/LAK regimen was used in cancer patients at six extramural cancer centers. In this report we will review our experience with mononuclear cell removal from the blood of cancer patients using apheresis technology and extracorporeal handling of these cells to generate a selective, highly cytotoxic cell population. |
| Databáze: | OpenAIRE |
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