Stepwise implementation of a low-cost and portable radiofrequency hyperthermia system for in vitro/in vivo cancer studies
Autor: | Göknur Güler Öztürk, I. Cengiz Koçum, Fatih Senturk |
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Přispěvatelé: | [Belirlenecek] |
Rok vydání: | 2021 |
Předmět: |
Hyperthermia
General Chemical Engineering 02 engineering and technology 01 natural sciences Radiofrequency (RF) power generator medicine In vitro in vivo Instrumentation General Environmental Science business.industry 010401 analytical chemistry Hyperthermia system Cancer Hyperthermia Treatment Biological tissue 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Radiofrequency (RF) amplifier Magnetic Hyperthermia Cancer research Nanoparticles 13.56 MHz generator 0210 nano-technology business Principles |
DOI: | 10.6084/m9.figshare.14646565.v1 |
Popis: | In recent years, interactions of radiofrequency (RF) electromagnetic fields with biological tissue have become one of the most promising strategies for noninvasive cancer hyperthermia treatment. Despite the growing interest, there has been a scarcity of studies involving the detailed construction of a complete RF-hyperthermia (RF-HT) system. Here a low-cost and high-power RF-HT system is reported with a specific frequency which can be used in biological samples. A laboratory-constructed RF-HT system composed of a radiofrequency oscillator, radiofrequency driver, radiofrequency amplifier, radiofrequency matching network, and an induction coil applicator were constructed and characterized by a stepwise approach. Although the RF driver and amplifier were purchased as professionally designed kits, significant modifications were required for these components. The results showed that the RF-HT system was successfully constructed and tested at 13.56 MHz with a power as high as 400 W. As a preliminary biological experiment, cell culture medium exhibited an approximate 3 degrees C increase in temperature induced by the RF-HT device at 250 W for 10 min. Moreover, the developed system is suitable drug targeting, drug release, and cellular uptake and designed to be cost-effective for in vitro/in vivo studies involving cancer therapy. Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-118S027, SBAG-119S137] This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) grant SBAG-118S027 and SBAG-119S137. WOS:000653058900001 |
Databáze: | OpenAIRE |
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