Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life
| Autor: | Kee Wei Phang, Hugo Van Bever, Keith M. Godfrey, Mary Foong-Fong Chong, Elizabeth Huiwen Tham, Oon Hoe Teoh, Evelyn Xiu Ling Loo, Lynette Pei-Chi Shek, Anne Goh, Yap Seng Chong, Peter D. Gluckman, Bee Wah Lee |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Allergy Offspring Immunology Physiology Disease Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Hypersensitivity medicine Humans Immunology and Allergy Prospective Studies 030212 general & internal medicine Vitamin D Skin Tests Asthma Singapore Fetus business.industry Immune regulation Infant Vitamin D Deficiency medicine.disease 030228 respiratory system Child Preschool Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Female business Maternal vitamin |
| Zdroj: | Pediatric Allergy and Immunology. 30:117-122 |
| ISSN: | 0905-6157 |
| DOI: | 10.1111/pai.12995 |
| Popis: | There is increasing evidence to support the Developmental Origins of Health and Disease (DOHaD) concept that fetal life and early life exposures are important determinants of fetal immune regulation and the development of disorders in later life, including allergies. Among the early life exposures, maternal vitamin D [25(OH)D] status during pregnancy, in particular 25(OH)D insufficiency (25(OH)D concentration of 50‐75nmol/l) and/or 25(OH)D deficiency (25(OH)D concentration |
| Databáze: | OpenAIRE |
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