Use of cardiac output to improve measurement of input function in quantitative dynamic contrast-enhanced MRI
| Autor: | Jeff L. Zhang, Vivian S. Lee, Henry Rusinek, Pippa Storey, Louisa Bokacheva, Qun Chen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Gadolinium DTPA Male Cardiac output Time Factors Correlation coefficient Monte Carlo method Contrast Media Kidney Article Electrocardiography Imaging Three-Dimensional medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Cardiac Output Aged Mathematics Aged 80 and over Reproducibility medicine.diagnostic_test business.industry Reproducibility of Results Input function Tumor therapy Magnetic resonance imaging Middle Aged Image Enhancement Magnetic Resonance Imaging Kidney Neoplasms Kinetics Area Under Curve Dynamic contrast-enhanced MRI Female Nuclear medicine business Monte Carlo Method |
| Zdroj: | Journal of Magnetic Resonance Imaging. 30:656-665 |
| ISSN: | 1522-2586 1053-1807 |
| Popis: | Purpose To validate a new method for converting MR arterial signal intensity versus time curves to arterial input functions (AIFs). Materials and Methods The method constrains AIF with patient's cardiac output (Q). Monte Carlo simulations of MR renography and tumor perfusion protocols were carried out for comparison with two alternative methods: direct measurement and population-averaged input function. MR renography was performed to assess the method's inter- and intraday reproducibility for renal parameters. Results In simulations of tumor perfusion, the precision of the parameters (Ktrans and ve) computed using the proposed method was improved by at least a factor of three compared to direct measurement. Similar improvements were obtained in simulations of MR renography. Volunteer study for testing interday reproducibility confirmed the improvement of precision in renal parameters when using the proposed method compared to conventional methods. In another patient study (two injections within one session), the proposed method significantly increased the correlation coefficient (R) between GFR of the two exams (0.92 vs. 0.83) compared to direct measurement. Conclusion A new method significantly improves the precision of dynamic contrast-enhanced (DCE) parameters. The method may be especially useful for analyzing repeated DCE examinations, such as monitoring tumor therapy or angiotensin converting enzyme-inhibitor renography. J. Magn. Reson. Imaging 2009;30:656–665. © 2009 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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