Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects
| Autor: | Wolfgang Jordan, Andreas Meier, Gerald Huether, Kathrin Pohlmann, Eckart Rüther, Zhenghua Guan, Stefan Cohrs, Andrea Rodenbeck |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Dibenzothiazepines Hydrocortisone medicine.drug_class Radioimmunoassay Bedtime Hypnotic Excretion Melatonin Quetiapine Fumarate Double-Blind Method Stress Physiological Internal medicine medicine Humans Pharmacology Cross-Over Studies Dose-Response Relationship Drug business.industry Dose-Response Relationship Radiation Circadian Rhythm Endocrinology Before Bedtime Acoustic Stimulation Multivariate Analysis Quetiapine business hormones hormone substitutes and hormone antagonists medicine.drug Antipsychotic Agents |
| Zdroj: | Psychopharmacology. 174(3) |
| ISSN: | 0033-3158 |
| Popis: | Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is a frequent finding in psychiatric disorders, including psychotic depression and schizophrenia. Conflicting results exist concerning the influence of antipsychotics on the HPA-axis. Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the effect of quetiapine on nocturnal urinary cortisol and melatonin excretion in 13 healthy male subjects under conditions of undisturbed and experimentally disturbed sleep. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Placebo, quetiapine 25 mg or quetiapine 100 mg was administered orally 1 h before bedtime on nights 1 and 2. Urine produced during the 8-h bedtime period was collected for later determination of cortisol and melatonin concentrations by standard radioimmunoassays. MANOVA showed a significant effect for N1 vs. N2 with elevated total amount of cortisol (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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