Cardiorespiratory responses to high-intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease
| Autor: | Stefan P. Mortensen, Ulrik Winning Iepsen, Paul J. Fadel, Niels H. Secher, Thales C. Barbosa, Peter Lange, Camilla Koch Ryrsø, Bente Klarlund Pedersen, Mette Rugbjerg, Pia Thaning |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
exercise pressor reflex
medicine.medical_specialty Mean arterial pressure Respiratory rate Physiology Blood Pressure 030204 cardiovascular system & hematology hemodynamics 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Heart Rate Physiology (medical) Internal medicine Heart rate Reflex Medicine Humans COPD Muscle Skeletal Exercise Hand Strength business.industry Skeletal muscle blood pressure Cardiorespiratory fitness 030229 sport sciences General Medicine medicine.disease exercise intolerance pulmonary rehabilitation medicine.anatomical_structure Blood pressure Cardiology business Respiratory minute volume Muscle Contraction |
| Zdroj: | Iepsen, U W, Ryrsø, C K, Rugbjerg, M, Secher, N H, Barbosa, T C, Lange, P, Thaning, P, Pedersen, B K, Mortensen, S P & Fadel, P J 2021, ' Cardiorespiratory responses to high-intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease ', Clinical Physiology and Functional Imaging, vol. 41, no. 2, pp. 146-155 . https://doi.org/10.1111/cpf.12678 Iepsen, U W, Ryrsø, C K, Rugbjerg, M, Secher, N H, Barbosa, T C, Lange, P, Thaning, P, Pedersen, B K, Mortensen, S P & Fadel, P J 2021, ' Cardiorespiratory responses to high intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease ', Clinical Physiology and Functional Imaging, vol. 41, no. 2, pp. 146-155 . https://doi.org/10.1111/cpf.12678 |
| DOI: | 10.1111/cpf.12678 |
| Popis: | Background: Augmented skeletal muscle metaboreflex activation may accompany chronic obstructive pulmonary disease (COPD). The maintained metaboreflex control of mean arterial pressure (MAP) that has been reported may reflect limited evaluation using only one moderate bout of static handgrip (HG) and following postexercise ischaemia (PEI). Objective: We tested the hypothesis that cardiovascular and respiratory responses to high-intensity static HG and isolated metaboreflex activation during PEI are augmented in COPD patients. Methods: Ten patients with moderate to severe COPD and eight healthy age- and BMI-matched controls performed two-minute static HG at moderate (30% maximal voluntary contraction; MVC) and high (40% MVC) intensity followed by PEI. Results: Despite similar ratings of perceived exertion, arm muscle mass and strength, COPD patients demonstrated lower MAP responses during both HG intensities compared with controls (time × group interaction, p .05). We found no between-group differences in heart rate, respiratory rate, or estimated minute ventilation during HG or PEI. Conclusion: These results suggest that the pressor response to high-intensity HG is blunted in COPD patients. Moreover, despite inducing a strong cardiovascular and respiratory stimulus, skeletal muscle metaboreflex activation evoked similar responses in COPD patients and controls. |
| Databáze: | OpenAIRE |
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