Repurposing benzbromarone for pulmonary arterial hypertension: can channelling the past deliver the therapy of the future?
| Autor: | Mark L. Ormiston, Anne L. Theilmann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Hypertension Pulmonary 3. Good health 03 medical and health sciences Benzbromarone chemistry.chemical_compound 0302 clinical medicine 030228 respiratory system chemistry Vasoconstriction Internal medicine medicine Cardiology Humans Familial primary pulmonary hypertension Familial Primary Pulmonary Hypertension 030212 general & internal medicine medicine.symptom business Repurposing |
| Zdroj: | The European respiratory journal. 53(6) |
| ISSN: | 1399-3003 |
| Popis: | A new study identifies increases in the calcium activated chloride channel, TMEM16A, in the pulmonary arteries of IPAH patients and proposes the repurposing of benzbromarone, a non-specific inhibitor of the channel, as a novel therapy for the diseasehttp://bit.ly/2ITN4ul |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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