Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour

Autor: Patrick Browaeys, Xenofon Giannakopoulos, Catherine Bruyns, Dominique Waroquier, Laura Harsan, Bernard Robaye, Thierry Velu, Gregory Driessens
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Annexin A5 -- metabolism
p53
Cancer Research
DNA Damage -- drug effects
Apoptosis
Micronuclei
chemotherapy
Annexin A5/metabolism
Brain Neoplasms/drug therapy/*genetics/radiotherapy
Tumor Suppressor Protein p53/*genetics
Brain Neoplasms -- drug therapy
Tumor Cells
Cultured
Annexin A5
Micronucleus Tests
Brain Neoplasms
Caspase 3
Caspases/metabolism
apoptosis
Glioma -- radiotherapy
DNA
Neoplasm
γ-irradiation
Glioma
Sciences bio-médicales et agricoles
DNA
Neoplasm/drug effects
Oncology
Cisplatin -- therapeutic use
Caspases
Glioma/drug therapy/*genetics/radiotherapy
Micronucleus test
Micronuclei
Chromosome-Defective -- genetics
medicine.drug
Programmed cell death
DNA damage
Tumor Suppressor Protein p53 -- genetics
Antineoplastic Agents
Biology
Brain Neoplasms -- genetics
complex mixtures
Glioma -- genetics
In vivo
medicine
In Situ Nick-End Labeling
Chemotherapy
Animals
Experimental Therapeutics
Micronuclei
Chromosome-Defective
Cisplatin
Brain Neoplasms -- radiotherapy
Apoptosis/drug effects
Antineoplastic Agents/therapeutic use
DNA
Neoplasm -- drug effects
medicine.disease
Caspases -- metabolism
Rats
Inbred F344
Rats
Glioma -- drug therapy
micronuclei
DNA Damage/drug effects
Cancer research
Antineoplastic Agents -- therapeutic use
Tumor Suppressor Protein p53
Cisplatin/therapeutic use
Micronuclei
Chromosome-Defective/*genetics
Apoptosis -- drug effects
DNA Damage
Zdroj: British Journal of Cancer, 89 (4
British Journal of Cancer
Popis: Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour.
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published
Databáze: OpenAIRE
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