Five New Terpenes with Cytotoxic Activity from Pestalotiopsis sp
| Autor: | Guo-Xu Ma, Dan Zhao, Meigeng Hu, Xudong Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Stereochemistry
Pestalotiopsis Proton Magnetic Resonance Spectroscopy Pharmaceutical Science Organic chemistry Antineoplastic Agents Sesquiterpene Article Analytical Chemistry Terpene chemistry.chemical_compound QD241-441 Cell Line Tumor Drug Discovery Cytotoxic T cell Humans Physical and Theoretical Chemistry Carbon-13 Magnetic Resonance Spectroscopy Antitumor activity cytotoxic activities biology Cell Death biology.organism_classification Pestalotiopsis sp lung cancer chemistry Chemistry (miscellaneous) Cell culture HuH-7 cell lines Molecular Medicine Ligusticum chuanxiong terpenes Derivative (chemistry) |
| Zdroj: | Molecules; Volume 26; Issue 23; Pages: 7229 Molecules, Vol 26, Iss 7229, p 7229 (2021) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26237229 |
| Popis: | Five new compounds called Pestalotis A–E (1–5), comprising three monoterpene-lactone compounds (1–3), one tetrahydrobenzofuran derivative (4), and one sesquiterpene (5), were isolated from the EtOAc extract of Pestalotiopsis sp. The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. All compounds were tested for antitumor activity against SW-480, LoVo, HuH-7, and MCF-7. The results showed that compounds 2 and 4 exhibited potent antitumor activity against SW-480, LoVo, and HuH-7 cell lines. Furthermore, compound 4 was assessed against HuH-7, and the results indicated that the rate of apoptosis was dose-dependent. |
| Databáze: | OpenAIRE |
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