Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients
| Autor: | Ekrem Cengiz Seyhan, Halim Issever, Sinan Trablus, Orhan Kaya Koksalan, Gulsah Gunluoglu, D. Yilmaz, Sinem Nedime Sökücü, Sedat Altin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Tuberculosis Turkey Population Tuberculin Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Mycobacterium tuberculosis Interferon-gamma Bacterial Proteins Latent Tuberculosis Renal Dialysis Internal medicine medicine Humans Medical history Prospective Studies Renal Insufficiency education Prospective cohort study Transplantation education.field_of_study Bacteriological Techniques Latent tuberculosis biology business.industry Tuberculin Test Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Recombinant Proteins Infectious Diseases Case-Control Studies Immunology Female business Oligopeptides |
| Zdroj: | Transplant infectious disease : an official journal of the Transplantation Society. 12(2) |
| ISSN: | 1399-3062 |
| Popis: | E.C. Seyhan, S. Sokucu, S. Altin, G. Gunluoglu, S. Trablus, D. Yilmaz, O.K. Koksalan, H. Issever. Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients. Transpl Infect Dis 2010: 12: 98–105. All rights reserved Background and objectives. Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis (TB) infection (LTBI). LTBI screening of this population is recommended. The QuantiFERON-TB Gold assay (QFT-G) may be more accurate than the tuberculin skin test (TST) in the detection of LTBI. We prospectively compared the results of QFT-G to TST in HD patients. Methods. We examined 100 patients and performed TST and QFT-G tests. Data obtained from patients and medical records included medical history (past history of TB, Bacillus Calmette–Guerin [BCG] vaccination, history of contact with previous TB cases), radiography reports (chest x-ray with changes consistent with old TB), and basic laboratory findings. Results. Forty-three of 100 patients (43%) had a positive QFT-G test result and 34 (34%) had a positive TST test result. Overall agreement between the QFT-G and the TST was 65% (concordance [k]=0.26, P=0.01). Discordant test results were seen in 13 TST-positive/QFT-G-negative patients and in 22 TST-negative/QFT-G-positive patients. Before BCG vaccination and radiographic reports (of old TB changes) were associated with discordant test results. On multivariate analysis, a positive QFT-G test was associated with contact with previous TB cases (P=0.026) and radiographic report (P=0.034), whereas a positive TST test also was associated with a history of BCG vaccination (P=0.015). Conclusions. QFT-G test results were more closely associated with TB risk factors than were positive TST results. Additionally, the QFT-G test was not affected by BCG vaccination. We concluded that QFT-G test is a more useful diagnostic method than TST for detecting LTBI in HD patients. |
| Databáze: | OpenAIRE |
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