Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry
| Autor: | Dongchon Kang, Toshiaki Ohkuma, Yuji Komorita, Tamaki Jodai-Kitamura, Hitoshi Ide, Akiko Sumi, Hiroki Fujii, Udai Nakamura, Masahito Yoshinari, Masanori Iwase, Takanari Kitazono |
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| Rok vydání: | 2017 |
| Předmět: |
Research design
Male Pediatrics medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Type 2 diabetes Body weight 03 medical and health sciences Fractures Bone 0302 clinical medicine Fragility Japan Weight loss Bone Density Risk Factors Diabetes mellitus Weight Loss Internal Medicine medicine Humans 030212 general & internal medicine Registries education Aged Advanced and Specialized Nursing Aged 80 and over education.field_of_study business.industry Body Weight Middle Aged medicine.disease Diabetes Mellitus Type 2 Female medicine.symptom business |
| Zdroj: | Diabetes care. 41(5) |
| ISSN: | 1935-5548 |
| Popis: | OBJECTIVE There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fracture risk. RESEARCH DESIGN AND METHODS A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: RESULTS During the follow-up period, fragility fractures occurred in 198 participants. The age- and sex-adjusted incidence rates per 1,000 person-years in all participants were 6.4 ( CONCLUSIONS The current study demonstrates that ≥20% body weight loss from maximum weight is a significant risk factor for fragility fractures in patients with type 2 diabetes, especially in men. |
| Databáze: | OpenAIRE |
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