Spinal Cord Neurosarcoidosis
| Autor: | Jinny Tavee, Mimi Sohn, Daniel A. Culver, Kenkichi Nozaki, Thomas F. Scott, Marc A. Judson |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Sarcoidosis Lesion Young Adult Cerebrospinal fluid Adrenal Cortex Hormones Central Nervous System Diseases Modified Rankin Scale Biopsy Humans Medicine Lung medicine.diagnostic_test business.industry Multiple sclerosis Neurosarcoidosis General Medicine Middle Aged medicine.disease Spinal cord Surgery Radiography medicine.anatomical_structure Spinal Cord Female Lymph Nodes medicine.symptom business Immunosuppressive Agents |
| Zdroj: | The American Journal of the Medical Sciences. 347:195-198 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/maj.0b013e3182808781 |
| Popis: | Background Spinal cord neurosarcoidosis (SN) is problematic to diagnose because it mimics other inflammatory0020neurologic diseases. The authors report the clinical features of 29 SN cases. Methods They retrospectively reviewed the medical records of 29 histologically proven sarcoidosis patients with spinal cord involvement seen at 3 university medical centers. They collected clinical data including laboratory and radiological findings. Clinical outcomes were assessed retrospectively using the modified Rankin scale. Results The cohort included high number of African Americans (16/29, 55%). The lung and intrathoracic lymph nodes were the most common confirmatory biopsy sites (18/29, 62%), whereas the spinal cord was a relatively uncommon one (4/29, 14%). The most common presenting symptoms were lower extremity weakness and paresthesias. Thoracic segment was most frequently involved (21/27, 78%). Lesions were mostly intramedullary (22/27, 81%), although nearly half involved the leptomeninges (13/27, 48%). The average size of a lesion spanned 3.9 spine segments (range, 1–9); 17 of 22 (77%) intramedullary patients had $3 spine segments involved. Angiotensin-converting enzyme levels in cerebrospinal fluid were elevated in only 2 of 11 (18%) patients. All patients received glucocorticosteroids. Additional immune-modulating agents were used in 24 of 29 (83%) patients. Scores on the modified Rankin scale at the final follow-up visit were improved. Conclusions Most SN cases were diagnosed indirectly based on extraneural tissue biopsy. Extended spinal cord lesion ($3 spine segments) may be useful to distinguish SN from multiple sclerosis. Cerebrospinal fluid analysis was of limited value. Most patients experienced clinical improvement with immunosuppressive treatment, but many required combination therapy. |
| Databáze: | OpenAIRE |
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