Drugs of Dependence Though Not of Abuse: Fenfluramine and Imipramine
| Autor: | D. L. F. Dunleavy, Stuart A. Lewis, Vlasta Brezinova, Ian Oswald, Marion Briggs |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Adult
Male Drug Imipramine Drugs of abuse Substance-Related Disorders Fenfluramine media_common.quotation_subject Appetite Depressants Phenethylamines medicine Humans Depression (differential diagnoses) General Environmental Science media_common Depression business.industry Body Weight General Engineering Fluorine Papers and Originals General Medicine Middle Aged Dreams Substance Withdrawal Syndrome Reduced appetite Mood Feeling Anesthesia General Earth and Planetary Sciences Female business medicine.drug |
| Zdroj: | BMJ. 3:70-73 |
| ISSN: | 1468-5833 0959-8138 |
| Popis: | Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal. An experiment in which another 11 patients took fenfluramine 80 mg for 28 days confirmed the depression, maximal on the fourth withdrawal day. It also indicated that in the first week of administration there was some mood elevation, but with feelings of impaired ability to concentrate. The drug reduced appetite and weight. A comparison is drawn with imipramine, which was found to induce initial and withdrawal changes of subjective experience (of dreaming) in six volunteers. It is suggested that certain mood-influencing drugs may not be drugs of abuse because of some unpleasant initial effects, though they can be drugs of dependence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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