Critical roles of TLRs on the polarization of mesenchymal stem cells for cell therapy of viral infections: a notice for COVID-19 treatment
| Autor: | Shiva Gholizadeh-Ghaleh Aziz, Ali Golchin, Arezo Azari, Parviz Ranjbarvan, Shahriar Alipour, Ghader Babaei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Anti-inflammatory agents
Autoimmune disease Viral infections 040301 veterinary sciences business.industry Cell Mesenchymal stem cell COVID-19 04 agricultural and veterinary sciences Brief Communication medicine.disease Toll-like receptors Pathology and Forensic Medicine Proinflammatory cytokine 0403 veterinary science Cell therapy medicine.anatomical_structure Graft-versus-host disease Immune system Immunology medicine Mesenchymal stem cells Anatomy business Receptor |
| Zdroj: | Comparative Clinical Pathology |
| ISSN: | 1618-565X 1618-5641 |
| DOI: | 10.1007/s00580-021-03209-0 |
| Popis: | Mesenchymal stem cells (MSCs), as one of the leading cell-based therapy, have provided a strong link between clinical investigation and basic research. MSCs have been successfully employed in treating graft versus host disease (GvHD), autoimmune disease, and several other diseases, particularly with high immune activity. Recently, MSCs have attracted attention to treating untreatable viral infections such as severe coronavirus disease 2019 (COVID-19). Given that the Toll-like receptors (TLRs) are directly able to detect internal and external hazard signals, and their stimulation has an intense effect on the ability to grow, differentiate, migrate, and maintain MSCs, it seems stimulation of these receptors can have a direct impact on the interaction of MSCs and immune cells, altering the ability to modify immune system responses. Hence, this mini-review focused on TLRs' critical roles in the polarization of MSCs for developing MSC-based therapy in viral infections. Consequently, according to the literature review, a polarization process, mediated by TLRs concerning anti-inflammatory and proinflammatory phenotype, may be considered for MSC-therapy against viral infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink