Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
| Autor: | Heung Yong Jin, Youn Soo Cha, Hong Sun Baek, Taesun Park |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male food.ingredient Antioxidant Peripheral nervous system diseases Time Factors medicine.medical_treatment Biology Diet High-Fat Neuroprotection Antioxidants Prediabetic State Mice food Diabetic Neuropathies Vitis vinifera grape seed extract Botany High fat medicine Animals Vitis Food science Peripheral Nerves Vitis vinifera Plants Medicinal Dose-Response Relationship Drug Grape Seed Extract fungi Body Weight food and beverages Lipids Mice Inbred C57BL Disease Models Animal Neuroprotective Agents Fat diet Proanthocyanidin Grape seed extract Original Article Epidermis Biomarkers Phytotherapy |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 1226-3303 |
| Popis: | Background/Aims Vitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD). Methods Mice were divided into four groups according to VVE dose: those fed a normal diet (ND; n = 10), HD (n = 10), HD with 100 mg/kg VVE (n = 10), and HD with 250 mg/kg VVE (n = 10). After 12 weeks, immunohistochemical analyses were carried out using a polyclonal antibody against antiprotein gene product 9.5 (protein-gene-product, 9.5), and intraepidermal innervation was subsequently quantified as nerve fiber abundance per unit length of epidermis (intraepidermal nerve fiber, IENF/mm). Results Daily administration of VVE at doses of 100 or 250 mg/kg for 12 weeks protected HD mice from nerve fiber loss compared to untreated mice, as follows (IENF/mm): controls (40.95 ± 5.40), HD (28.70 ± 6.37), HD with 100 mg/kg (41.14 ± 1.12), and HD with 250 mg/kg (48.98 ± 7.01; p < 0.05, HD with VVE vs. HD). Conclusions This study provides scientific support for the therapeutic potential of VVE in peripheral neuropathy in an HD mouse model. Our results suggest that VVE could play a role in the management of peripheral neuropathy, similar to other antioxidants known to be beneficial for diabetic peripheral neuropathy. |
| Databáze: | OpenAIRE |
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