Dextran sulfate sodium (DSS)-induced colitis in mice
| Autor: | Madhu Malleshappa, Benoit Chassaing, Matam Vijay-Kumar, Jesse D. Aitken |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Immunology Disease Inflammatory bowel disease digestive system Article Pathogenesis Feces Mice Medicine Animals Humans Colitis Dextran Sulfate Sodium Mice Inbred BALB C business.industry Body Weight Dextran Sulfate Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Chemically-induced colitis digestive system diseases Mice Inbred C57BL Disease Models Animal Female business Biomarkers |
| Zdroj: | Current Protocols in Immunology |
| ISSN: | 1934-368X |
| Popis: | Inflammatory bowel diseases (IBD) mainly comprised of Ulcerative Colitis and Crohn's Disease are complex and multifactorial disease with unknown etiology. For the past 20 years, to study human IBD mechanistically, number of murine models of colitis has been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate number potential therapeutics. Among various chemical induced colitis models, DSS-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that need to be considered when employed. The current protocol aimed to extensively describe the DSS-induced colitis model, focusing on its detailed protocol as well as factors that could affect DSS-induced pathology. |
| Databáze: | OpenAIRE |
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