Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole
| Autor: | I.T.M. Vermeer, Leopold G.J.B. Engels, D. M. F. A. Pachen, Jan M. S. van Maanen, Jan W. Dallinga, Jos C. S. Kleinjans |
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| Přispěvatelé: | Gezondheidsrisico Analyse en Toxicologie, Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Nitrosamines medicine.drug_class Biopsy Proton-pump inhibitor Gastroenterology Helicobacter Infections Excretion chemistry.chemical_compound Risk Factors Stomach Neoplasms Internal medicine medicine Humans Nitrite Nitrites Omeprazole Aged Aged 80 and over Gastric Juice Helicobacter pylori Hepatology biology business.industry Stomach Proton Pump Inhibitors Hydrogen-Ion Concentration Middle Aged Anti-Ulcer Agents biology.organism_classification medicine.anatomical_structure chemistry Biochemistry Nitrosamine Gastric acid Female business medicine.drug |
| Zdroj: | Gastroenterology, 121, 517-525. Elsevier Saunders |
| ISSN: | 0016-5085 |
| Popis: | Gastroenterology 2001 Sep;121(3):517-25 Related Articles, Books, LinkOut Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole.Vermeer IT, Engels LG, Pachen DM, Dallinga JW, Kleinjans JC, van Maanen JM.Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands. Ingrid.Vermeer@numico-research.nlBACKGROUND & AIMS: This study evaluated the effect of long-term gastric acid suppressive therapy with omeprazole on intragastric levels of carcinogenic N-nitrosamines and related parameters. METHODS: Forty-five patients on long-term omeprazole medication (mean, 35 months) and 13 healthy subjects without medication participated. Volatile N-nitrosamines were determined in gastric juice and urine. Intragastric pH, nitrite, nitrate, and H. pylori status were determined. DNA isolated from gastric biopsy specimens was analyzed for precarcinogenic alkyl-DNA adducts. RESULTS: The intragastric pH in patients was significantly higher compared with controls (P = 0.0001). Gastric nitrite levels in patients were nonsignificantly higher. There was no difference in total levels of intragastric volatile N-nitrosamines between patients and controls, however, urinary N-nitrosodimethylamine excretion was higher in patients (P = 0.001). On omeprazole, Helicobacter pylori-positive vs. -negative patients had a nonsignificantly higher intragastric nitrite level and higher urinary N-nitrosodimethylamine excretion. No alkyl-DNA adducts could be detected in gastric epithelium. CONCLUSIONS: Increased intragastric pH caused by long-term treatment with omeprazole does not result in increased intragastric levels of nitrite and volatile N-nitrosamines. The significantly higher urinary N-nitrosamine excretion implies the risk of increased endogenous formation of N-nitrosamines during long-term omeprazole treatment. This risk may be higher in H. pylori-positive patients. |
| Databáze: | OpenAIRE |
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