High-field and benchtop NMR spectroscopy for the characterization of new psychoactive substances
| Autor: | Fabrice Besacier, Jonathan Farjon, Virginie Ladroue, Patrick Giraudeau, Thomas Castaing-Cordier, Audrey Bulete, Denis Jacquemin |
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| Přispěvatelé: | Modélisation Et Spectroscopie (ModES), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut National de Police Scientifique (INPS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Benchtop NMR spectrometer
Materials science Magnetic Resonance Spectroscopy Nanotechnology High field NMR spectroscopy 01 natural sciences Mass Spectrometry Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Quantification MESH: Benchtop NMR spectrometer New psychoactive substances Structure elucidation Humans [CHIM]Chemical Sciences 030216 legal & forensic medicine Chromatography High Pressure Liquid Psychotropic Drugs Illicit Drugs 010401 analytical chemistry Nuclear magnetic resonance spectroscopy 0104 chemical sciences Characterization (materials science) High field Law |
| Zdroj: | Forensic Science International Forensic Science International, Elsevier, 2021, 321, pp.110718. ⟨10.1016/j.forsciint.2021.110718⟩ |
| ISSN: | 0379-0738 |
| DOI: | 10.1016/j.forsciint.2021.110718⟩ |
| Popis: | International audience; New psychoactive substances (NPS) have become a serious threat for public health in Europe due to their ability to be sold in the street or on the darknet. Regulating NPS is an urgent priority but comes with a number of analytical challenges since they are structurally close to legal products. A number of analytical techniques can be used for identifying NPS, among which NMR spectroscopy is in the limelight. High field NMR is typically used for structural elucidation in combination with others techniques like GC-MS, Infrared spectroscopy, together with databases. In addition to their strong ability to elucidate molecular structures, high field NMR techniques are the gold standard for quantification without any physical isolation procedure and with a single internal standard. However, high field NMR remains expensive and emerging "benchtop" NMR apparatus which are cheaper and transportable can be considered as valuable alternatives to high field NMR. Indeed, benchtop NMR, which has emerged about ten years ago, makes it possible to carry out structural elucidation and quantification of new psychoactive substances despite the gap in resolution and sensitivity as compared to high field NMR. This review describes recent advances in the field of NMR applied to the characterization of NPS. High-field NMR methods are first described in view of their complementarity with other analytical methods, focusing on both structural and quantitative aspects. The second part of the review highlights how emerging benchtop NMR approaches could act as a game changer in the field of forensics. |
| Databáze: | OpenAIRE |
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