Green cationic arginine surfactants: Influence of the polar head cationic character on the self-aggregation and biological properties
| Autor: | Aurora Pinazo, Anderson Ramos da Silva, Francisco Fábio Oliveira de Sousa, María del Carmen Morán, Ramon Pons, Lourdes Pérez |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Arginine
Small-angle X-ray scattering Surfactants Cationic polymerization Monolayer Biological membrane Condensed Matter Physics Atomic and Molecular Physics and Optics Antibiofilm Electronic Optical and Magnetic Materials Liquid Crystals chemistry.chemical_compound Membrane chemistry Pulmonary surfactant Amide Materials Chemistry Organic chemistry Antimicrobial Physical and Theoretical Chemistry Spectroscopy |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Green surfactants are compounds derived from renewable sources of raw material that exhibit biodegradability and low toxicity. In this work the synthesis, solution, aggregation and biological properties of two families of green cationic arginine based surfactants have been investigated, Nα-acyl arginine methyl ester and arginine N-alkyl amide. Specifically we study: (i) the effect of self-aggregation on the cationic character, (ii) Liquid crystalline phases applying SAXS, (iii) surfactant ability to interact with biological membranes using Langmuir DPPC monolayers as a simple membrane model, (iv) biological profiles obtained by evaluation of antibacterial, anti-yeast and antibiofilm properties and, (v) the hemolytic activity on erythrocytes. The experiments conducted showed that the biological properties of arginine based surfactants were outstanding. These along with the fact that they are derived from green raw materials confer to these surfactants an outstanding potential in the field of green antimicrobial and antibiofilm agents. This research was founded by the Ministerio de Economia y Competitividad, Spain under grant # CTQ 2017 – 88948 – P and by European Regional Development Fund (FEDER). F. Fabio Oliveira was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and by the National Program of Cooperation in the Amazon – PROCAD/Amazon of Coordination of Superior Level Staff Improvement – CAPES/Brazil. |
| Databáze: | OpenAIRE |
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