Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis
| Autor: | Ronald I. Siphanto, T. G. van Leeuwen, J.W. van Neck, Wiendelt Steenbergen, Roy G. M. Kolkman, K.K. Thumma, F.F.M. de Mul, L. N. A. van Adrichem |
|---|---|
| Přispěvatelé: | Biomedical Engineering and Physics, Faculty of Science and Technology, Biomedical Photonic Imaging, Plastic and Reconstructive Surgery and Hand Surgery |
| Rok vydání: | 2005 |
| Předmět: |
Tumor angiogenesis
medicine.medical_specialty Materials science medicine.diagnostic_test genetic structures business.industry Ultrasound Photoacoustic imaging in biomedicine Laser medicine.disease Atomic and Molecular Physics and Optics law.invention Photoacoustic Doppler effect Neovascularization Optics Positron emission tomography law Pancreatic tumor medicine Medical physics sense organs medicine.symptom business Biomedical engineering |
| Zdroj: | Optics express, 13(1), 89-95. The Optical Society Optics Express, 13(1), 89-95. The Optical Society |
| ISSN: | 1094-4087 |
| Popis: | We present photoacoustic images of tumor neovascularization obtained over a 10-day period after subcutaneous inoculation of pancreatic tumor cells in a rat. The images were obtained from ultrasound generated by absorption in hemoglobin of short laser pulses at a wavelength of 1064 nm. The ultrasound signals were measured in reflection mode using a single scanning piezodetector, and images were reconstructed with a weighted delay-and-sum algorithm. Three-dimensional data visualize the development and quantify the extent of individual blood vessels around the growing tumor, blood concentration changes inside the tumor and growth in depth of the neovascularized region. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|