MicroRNAs as stress regulators in pancreatic beta cells and diabetes
| Autor: | Markus Stoffel, Mary P. LaPierre |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Inflammatory stress Signal modulation Disease Review Biology Bioinformatics 03 medical and health sciences 0302 clinical medicine miRNAs Pancreatic β-cells Insulin secretion Diabetes Stress Physiological Diabetes mellitus Pancreatic beta Cells Insulin-Secreting Cells microRNA medicine Diabetes Mellitus Animals Humans Obesity lcsh:RC31-1245 Molecular Biology Cell survival Cell Proliferation Cell Differentiation Cell Biology medicine.disease Cell biology MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Function (biology) Biomarkers |
| Zdroj: | Molecular Metabolism, Vol 6, Iss 9, Pp 1010-1023 (2017) Molecular Metabolism Molecular Metabolism, 6 (9) |
| DOI: | 10.3929/ethz-b-000192533 |
| Popis: | Background MicroRNAs have emerged as important regulatory non-coding RNAs that tune cellular responses to physiological perturbations and disease conditions. An increasing body of literature underlines the important roles of miRNA function in pancreatic β-cells in response to metabolic, genetic and inflammatory stress. Lessons from genetic loss- and gain-of-function studies have implicated several highly expressed and evolutionary conserved miRNAs in stress signal modulation, resolution and buffering, thereby forming stabilizing miRNA networks that preserve β-cell differentiation, function, proliferation and cell survival. Scope of Review This review will summarize our current knowledge of how biologically relevant miRNAs regulate stress responses in pancreatic β-cells, discuss the challenges and opportunities associated with using secreted miRNAs as biomarkers and forecast how mechanistic knowledge of miRNA function can be exploited in developing miRNA-based therapeutics. Major Conclusions miRNAs play important roles in the function, differentiation, proliferation, and survival of pancreatic β-cells. Many miRNA families that are regulated by metabolic, genetic, and inflammatory stressors have been found to coordinate the adaptive responses of β-cells in vivo in conditions such as obesity and diabetes. Molecular Metabolism, 6 (9) |
| Databáze: | OpenAIRE |
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