Inhibition and Disruption Properties of Chlorhexidine Gluconate on Single and Multispecies Oral Biofilms
| Autor: | May Korachi, Gulhas Solmaz |
|---|---|
| Přispěvatelé: | Solmaz, G., Korachi, M., Yeditepe Üniversitesi |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Aggregatibacter Chlorhexidine gluconate Anti-microbial medicine.disease_cause Microbiology Agent medicine Periodontitis biology Streptococcus business.industry Biofilm biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Antimicrobial Streptococcus mutans stomatognathic diseases Infectious Diseases Fusobacterium Biofilms Fusobacterium nucleatum business |
| Zdroj: | Jundishapur Journal of Microbiology. 6:61-66 |
| ISSN: | 2008-4161 2008-3645 |
| DOI: | 10.5812/jjm.4852 |
| Popis: | Background: Chlorhexidine gluconate (CHX) is the most common antimicrobial agent used against oral pathogens, however information on its ability to inhibit and disrupt anaerobic single and multispecies biofilms is relatively unknown. Objectives: The purpose of this study was to test the efficacy of CHX for its biofilm inhibition and disruption properties using crystal violet assay. Materials and Methods: Biofilm assays were carried out on single and multispecies of four oral pathogens: Streptococcus mutans, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Results: Streptococcus mutans, Fusobacterium nucleatum and multi-species biofilm formation were inhibited in more than 90% of cases at concentrations of 3-12 mg/L. CHX exhibited strong disruptive activity (> 65%) on one-day old biofilms of A. actinomycetemcomitans and P. gingivalis. Conclusions: In conclusion, CHX was a high effective biofilm inhibitor on S. mutans, F. nucleatum and multispecies biofilms but had a minimal effect on P. gingivalis and A. actinomycetemcomitans. Conversely, CHX showed disruptive properties on late colonizers in single species biofilms but not on early colonizers and multispecies biofilms. © 2013 Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp. |
| Databáze: | OpenAIRE |
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