Effects of aqueous cinnamon extract on chemically-induced carcinoma of hamster cheek pouch mucosa
| Autor: | Mazen T. AbuElkhair, Mohamed I. Mourad, Mohamed E. Helal, Samah K. Ezzat, Mohammed E. Grawish |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
PAS reaction Group ii Biophysics DMBA Pharmacology Biology Biochemistry lcsh:Biochemistry 03 medical and health sciences 0302 clinical medicine Cheek pouch Squamous cell carcinoma Carcinoma medicine lcsh:QD415-436 lcsh:QH301-705.5 Syrian hamsters Cancer Buccal administration medicine.disease Hamster cheek pouch mucosa CD3 and PDGF immunoreactivity 030104 developmental biology lcsh:Biology (General) Aqueous cinnamon extract 030220 oncology & carcinogenesis Immunology Immunohistochemistry Research Article |
| Zdroj: | Biochemistry and Biophysics Reports Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 72-78 (2017) |
| ISSN: | 2405-5808 |
| Popis: | This study aimed to investigate the effects of aqueous cinnamon extract (ACE) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch (HCP) mucosa. Sixty male Syrian hamsters were randomly divided into six equal groups. The hamsters of groups I, II and III received no treatment, DMBA and ACE respectively, for 16 weeks. Groups IV and V were handled as group II and concomitantly treated with ACE for the same period and additionally group V received ACE for other 16 weeks after the stoppage of DMBA application. Group VI hamsters were handled as group III and additionally received DMBA for other 16 weeks after the stoppage of ACE supplementation. Hamsters of each group were euthanized according to the experimental schedule. The buccal pouches were and prepared for H&E stain, PAS reagent, CD3 and PDGF immunohistochemical reactivity. All groups showed dysplastic changes with varying degrees except groups I and III. Deep invasive carcinomas were recorded in 90% of the samples of group II, 60% of group IV, 50% of group V and 40% of group VI. From the previous results, it can be concluded that ACE has the potentiality preventing oral cancer initiation better than inhibiting oral cancer progression. |
| Databáze: | OpenAIRE |
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