A unique late-replicating XY to autosome translocation in Peromyscus melanophrys
| Autor: | Rachel J. O’Neill, Elisabeth E. Mlynarski, Craig Obergfell, Michael J. Dewey |
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| Rok vydání: | 2010 |
| Předmět: |
DNA Replication
Male Genetics X Chromosome Autosome Peromyscus Karyotype Biology Y chromosome biology.organism_classification Translocation Genetic X-inactivation Chromosome Painting X Chromosome Inactivation Heterochromatin Y Chromosome Animals Female Small supernumerary marker chromosome Sex linkage X chromosome |
| Zdroj: | Chromosome Research. 18:179-189 |
| ISSN: | 1573-6849 0967-3849 |
| Popis: | We report on the characterization of the Peromyscus melanophrys karyotype and sex chromosome system. Classic studies reported the sex chromosome system of this species may be as complex as an X(1)X(1)X(2)X(2)/X(1)X(2)Y(1)Y(2) and provided conflicting identification of the X chromosome. Using Peromyscus maniculatus chromosome paints, we have positively identified the sex chromosomes and clarified the sex determining system that once perplexed Peromyscus researchers. The sex chromosomes are characterized by a unique autosomal translocation of DNA shared between both the X and Y chromosomes. The translocated material is late replicating and heterochromatic yet retains the active chromatin conformation. Thus, autosomal regions derived from translocations involving repeat-rich material may retain some epigenetic marks specific to the sex chromosomes despite loss of epigenetic silencing activity. |
| Databáze: | OpenAIRE |
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