Neuropathic and inflammatory antinociceptive effects and electrocortical changes produced by Salvia divinorum in rats
| Autor: | Karina Simón-Arceo, Rodrigo Fernández-Mas, Angélica Almanza, Ulises Coffeen, Orlando Jaimes, Francisco Mercado, Bernardo Contreras, Francisco Pellicer, Ma. Eva González-Trujano |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.drug_class Analgesic Population Anti-Inflammatory Agents Pharmacology κ-opioid receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Opioid receptor Drug Discovery medicine Animals Salvia Rats Wistar education Cerebral Cortex Analgesics education.field_of_study Plant Extracts Salvinorin business.industry Receptors Opioid kappa Carbamazepine Rats 030104 developmental biology Nociception chemistry Celecoxib Neuralgia business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 206:115-124 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2017.05.016 |
| Popis: | Ethnopharmacological relevance Salvia divinorum is a medicinal plant traditionally used in hallucinogenic ethnopharmacological practices and for its analgesic and antinflammatory properties. Its active compounds include diterpenes known as salvinorins which act as potent κ opioid receptor agonists. Aim of the study Given its effects in acute animal models of pain, as well as its antinflammatory attributes, we decided to investigate the analgesic effects of an SD extract in neuropathic (sciatic loose nerve ligature) and inflammatory (intra plantar carrageenan) pain models in rats. We also determined in this study the electrocorticographic changes to correlate similar hallucinogenic state and behavior as those produced in humans. Material and methods Mechanical and thermonociceptive responses, plantar test and von Frey assay, respectively, were measured in adult Wistar rats 30 min, 3 h and 24 h after the intraperitoneal administration of saline or an hydroponic SD extract. We also evaluated carbamazepine and celecoxib, as gold reference drugs, to compare its antinociceptive effects. Results Our results showed that administration of SD extract induced antialgesic effects in both neuropathic and inflammatory pain models. All those effects were blocked by nor-binaltorphimine (a Kappa opioid receptor antagonist). Moreover, it was observed an increase of the anterior power spectral density and a decrease in the posterior region as electrocorticographic changes. Conclusion The present investigation give evidence that SD is capable to reduce algesic response associated to neuropathic and inflammatory nociception. This study support therapeutic alternatives for a disabling health problem due to the long term pain with high impact on population and personal and social implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect