Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis

Autor: Sandra Casimiro, Ana C Martins Cavaco, Sara Dâmaso, Luis Costa
Přispěvatelé: Repositório da Universidade de Lisboa
Rok vydání: 2020
Předmět:
Zdroj: Cancer and Metastasis Reviews. 39:603-623
ISSN: 1573-7233
0167-7659
DOI: 10.1007/s10555-020-09888-5
Popis: © Springer Science+Business Media, LLC, part of Springer Nature 2020
Progression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Desmoplasia and collagen biomarkers have been associated with relapse and death in cancer patients. Despite the increasing interest in ECM and in the desmoplastic process in tumor microenvironment as prognostic factors and therapeutic targets in cancer, further research is required for a better understanding of these aspects of cancer biology. In this review, published evidence correlating collagen with cancer prognosis is retrieved and analyzed, and the role of collagen and its fragments in cancer pathophysiology is discussed.
Databáze: OpenAIRE
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