Screening of the small molecule library of Meinox enables the identification of anticancer compounds in pathologically distinct cancers
| Autor: | Fatih Kocabas, Arif Mermer, Aynura Mammadova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Molecular mass
Physiology Chemistry Cancer Cell Biology Druglikeness medicine.disease Microbiology Small molecule Phenotype In vitro Article small molecules Biochemistry Genetics medicine Screening Adenocarcinoma cytotoxicity General Agricultural and Biological Sciences Cytotoxicity Molecular Biology Meinox small molecule library |
| Zdroj: | Turkish Journal of Biology |
| ISSN: | 1303-6092 |
| Popis: | Small molecules are widely used for the modulation of the molecular basis of diseases. This makes them the perfect tool for discovering and developing new therapeutics. In this work, we have established a library of small molecules in house and characterized its molecular and druglike properties. We have shown that most small molecules have molecular weights less than 450. They have pharmaceutically relevant cLogP, cLogS, and druglikeness value distributions. In addition, Meinox's small molecule library contained small molecules with polar surface areas that are less than 60 square angstroms, suggesting their potent ability to cross the blood-brain barrier. Meinox's small molecule library was also tested in vitro for pathologically distinct forms of cancer, including pancreatic adenocarcinoma PANC1, breast carcinoma MCF7, and lymphoblastic carcinoma RS4-11 cell lines. Analysis of this library at a dose of 1 μM allowed the discovery of potent, specific or broadly active anticancer compounds against pathologically distinct cancers. This study shows that in vitro analysis of different cancers or other phenotypic assays with Meinox small molecule library may generate novel and potent bioassay-specific compounds. |
| Databáze: | OpenAIRE |
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