The role of microenvironment and immunity in drug response in leukemia
| Autor: | Marija Krstic-Demonacos, Malak Qattan, Emyr Bakker, Luciano Mutti, Constantinos Demonacos |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microenvironment Novel therapeutics Antineoplastic Agents Bone Marrow Cells built_and_human_env Metastasis 03 medical and health sciences 0302 clinical medicine Bone Marrow medicine Tumor Microenvironment Humans Molecular Biology Cancer Inflammation Tumor microenvironment Leukemia business.industry Immunity Models Immunological A100 Cell Biology A300 medicine.disease Microvesicles Immune surveillance 030104 developmental biology medicine.anatomical_structure Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Immunology Neoplastic Stem Cells Bone marrow business Adult stem cell |
| Zdroj: | Biochimica et biophysica acta. 1863(3) |
| ISSN: | 0006-3002 0167-4889 |
| Popis: | Leukemia is a cancer of the white blood cells, with over 54,000 new cases per year diagnosed worldwide and a 5-year survival rate below 60%. This highlights a need for research into the mechanisms behind its etiology and causes of therapy failure. The bone marrow microenvironment, in which adult stem cells are maintained in healthy individuals, has been implicated as a source of chemoresistance and disease relapse. Here the various ways that the microenvironment can contribute to the resistance and persistence of leukemia are discussed. The targeting of the microenvironment by leukemia cells to create an environment more suitable for cancer progression is described. The role of soluble factors, drug transporters, microvesicles, as well as the importance of direct cell–cell contact, in addition to the effects of inflammation and immune surveillance in microenvironment-mediated drug resistance are discussed. An overview of the clinical potential of translating research findings to patients is also provided. Understanding of and further research into the role of the bone marrow microenvironment in leukemia progression and relapse are crucial towards developing more effective treatments and reduction in patient morbidity. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza. |
| Databáze: | OpenAIRE |
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