Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso):a randomised, double-blind, placebo-controlled trial
| Autor: | C B Okeke Ogwulu, Laura Jones, Leanne Beeson, Shilpa Deb, Kalsang Bhatia, Jackie Ross, Chitra S Kumar, Jenny H La Fontaine Papadopoulos, Abigail Oliver, Justin Chu, Meenakshi Choudhary, Natalie Nunes, Ying Cheong, Judith Hamilton, J. Naftalin, Pratima Gupta, Yongzhong Sun, Rachel Small, Andrew W Horne, Cecilia Bottomley, Adam J. Devall, Eleanor Williams, Linda Watkins, Arri Coomarasamy, Tracy E Roberts, Frances Hodge, A. Ahmed, Siobhan Quenby, A. Shahid, Ismail Hassan, Ioannis D. Gallos, Pollyanna Hardy, Yadava B. Jeve, Versha Cheed, Jane Brewin, Ruth Bender-Atik, Martyn Underwood, Kim Hinshaw, Stewart Pringle, Feras Izzat |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty mifepristone Placebo-controlled study placebo-controlled 030204 cardiovascular system & hematology Abortion Placebo law.invention Miscarriage 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method law Oxytocics Medicine Humans 030212 general & internal medicine Misoprostol misoprostol Pregnancy missed miscarriage business.industry Obstetrics General Medicine Mifepristone Articles medicine.disease Treatment Outcome Drug Therapy Combination RG Abortion Missed business randomised medicine.drug |
| Zdroj: | Chu, J J, Devall, A J, Beeson, L E, Hardy, P, Cheed, V, Sun, Y, Roberts, T E, Ogwulu, C O, Williams, E, Jones, L L, La Fontaine Papadopoulos, J H, Bender-Atik, R, Brewin, J, Hinshaw, K, Choudhary, M, Ahmed, A, Naftalin, J, Nunes, N, Oliver, A, Izzat, F, Bhatia, K, Hassan, I, Jeve, Y, Hamilton, J, Deb, S, Bottomley, C, Ross, J, Watkins, L, Underwood, M, Cheong, Y, Kumar, C S, Gupta, P, Small, R, Pringle, S, Hodge, F, Shahid, A, Gallos, I D, Horne, A W, Quenby, S & Coomarasamy, A 2020, ' Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso) : a randomised, double-blind, placebo-controlled trial ', The Lancet, vol. 396, no. 10253, pp. 770-778 . https://doi.org/10.1016/S0140-6736(20)31788-8 Lancet (London, England) |
| ISSN: | 0140-6736 |
| Popis: | Background\ud The anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of mifepristone and misoprostol is more effective than administering misoprostol alone. We investigated whether treatment with mifepristone plus misoprostol would result in a higher rate of completion of missed miscarriage compared with misoprostol alone. \ud \ud Methods\ud MifeMiso was a multicentre, double-blind, placebo-controlled, randomised trial in 28 UK hospitals. Women were eligible for enrolment if they were aged 16 years and older, diagnosed with a missed miscarriage by pelvic ultrasound scan in the first 14 weeks of pregnancy, chose to have medical management of miscarriage, and were willing and able to give informed consent. Participants were randomly assigned (1:1) to a single dose of oral mifepristone 200 mg or an oral placebo tablet, both followed by a single dose of vaginal, oral, or sublingual misoprostol 800 μg 2 days later. Randomisation was managed via a secure web-based randomisation program, with minimisation to balance study group assignments according to maternal age ( |
| Databáze: | OpenAIRE |
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