The effect of GHRH on TSH release in rats in vivo and in vitro
| Autor: | R. P. L. M. Hoogma, Ferdinand Roelfsema, B. J. Looij, D. van der Heide, J.P. Schröder van der Elst, A. C. Nieuwenhuijzen Kruseman |
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| Rok vydání: | 1995 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pituitary gland endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin Thyrotropin-releasing hormone Biology Peptide hormone Growth Hormone-Releasing Hormone Basal (phylogenetics) Endocrinology TRH stimulation test Pituitary Gland Anterior In vivo Internal medicine medicine Animals Rats Wistar Thyrotropin-Releasing Hormone Drug Synergism Growth hormone–releasing hormone Rats Kinetics medicine.anatomical_structure Mechanism of action medicine.symptom hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Endocrinological Investigation. 18:214-219 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03347804 |
| Popis: | In man, GHRH has been shown to potentiate the TSH-releasing activity of TRH. To study the way by which GHRH affects TRH-stimulated TSH release, we examined the effect of GHRH (1-29)NH2 on basal and stimulated TSH secretion in intact male rats and superfused dispersed rat pituitary cells. In the intact rats, GHRH(1-29)NH2 potentiated TRH-stimulated TSH release in the evening, but potentiation was not observed in the morning and in dispersed pituitary cells. Basal TSH levels were not changed by GHRH(1-29)NH2. It is concluded that GHRH(1-29)NH2 potentiates the TSH-releasing activity of TRH in the evening in rats possibly through suprahypophyseal disinhibition. |
| Databáze: | OpenAIRE |
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