68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy
| Autor: | Penelope Bouziotis, Anastasios Gaitanis, Eloise Thomas, Stavros Xanthopoulos, François Lux, Charles Truillet, Lia A. Moulopoulos, Dimitris Stellas, Vassilis Koutoulidis, Charalampos Tsoukalas, Theodoros Tsotakos, Maria Paravatou-Petsotas, Olivier Tillement, Constantinos Anagnostopoulos |
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| Přispěvatelé: | National Center for Scientific Research 'Demokritos' (NCSR), Department of Cancer Biology, Biomedical Research Foundation of the Academy of Athens, Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), First Department of Radiology, School of Medicine, National and Kapodistrian University of Athens (NKUA) |
| Rok vydání: | 2017 |
| Předmět: |
Biodistribution
medicine.medical_specialty Materials science [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Bioengineering [CHIM.THER]Chemical Sciences/Medicinal Chemistry 02 engineering and technology Development 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine In vivo medicine ultrasmall AGuIX nanoparticles General Materials Science PET/MR imaging medicine.diagnostic_test business.industry Gallium-68 Magnetic resonance imaging 021001 nanoscience & nanotechnology medicine.disease Radiation therapy Positron emission tomography [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Dual modality Radiology 0210 nano-technology Nuclear medicine business Ex vivo Glioblastoma |
| Zdroj: | Nanomedicine Nanomedicine, Future Medicine, 2017, 12 (13), pp.1561-1574. ⟨10.2217/nnm-2017-0032⟩ |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm-2017-0032 |
| Popis: | Aim: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (68Ga). Materials & methods: AGuIX@NODAGA nanoparticles were labeled with 68Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. Results: 68Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts. Metabolite assessment in serum, urine and tumor samples showed that 68Ga-AGuIX@NODAGA remains unmetabolized up to at least 60 min postinjection. Conclusion: This study demonstrates that 68Ga-AGuIX@NODAGA can be used as a dual-modality PET/MR imaging agent with passive accumulation in the diseased area, thus showing great potential for PET/MR image-guided radiation therapy. |
| Databáze: | OpenAIRE |
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