Biomarkers in differentiating clinical dengue cases: A prospective cohort study
| Autor: | Shu Cheow Ho, Seng Chiew Gan, Gary Kim, Kuan Low |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Vascular endothelial growth factor-A Thrombomodulin Subgroup analysis Pentraxin 3 Neopterin Dengue fever chemistry.chemical_compound Internal medicine medicine Warning signs Prospective cohort study lcsh:QH301-705.5 Severe dengue lcsh:R5-920 business.industry Cancer Soluble vascular cell adhesion molecule 1 medicine.disease lcsh:Biology (General) chemistry Immunology Mann–Whitney U test Biomarker (medicine) lcsh:Medicine (General) business |
| Zdroj: | Journal of Coastal Life Medicine, Vol 3, Iss 12, Pp 967-970 (2015) |
| ISSN: | 2309-6152 2309-5288 |
| DOI: | 10.12980/jclm.3.2015j5-141 |
| Popis: | Objective: To evaluate five biomarkers (neopterin, vascular endothelial growth factor-A, thrombomodulin, soluble vascular cell adhesion molecule 1 and pentraxin 3) in differentiating clinical dengue cases. Methods: A prospective cohort study was conducted whereby the blood samples were obtained at day of presentation and the final diagnosis were obtained at the end of patients’ follow-up. All patients included in the study were 15 years old or older, not pregnant, not infected by dengue previously and did not have cancer, autoimmune or haematological disorder. Median test was performed to compare the biomarker levels. A subgroup Mann-Whitney U test was analysed between severe dengue and non-severe dengue cases. Monte Carlo method was used to estimate the 2-tailed probability (P) value for independent variables with unequal number of patients. Results: All biomarkers except thrombomodulin has P value < 0.001 in differentiating among the healthy subjects, non-dengue fever, dengue without warning signs and dengue with warning signs/severe dengue. Subgroup analysis for all the biomarkers between severe dengue and non-severe dengue cases was not statistically significant except vascular endothelial growth factor-A (P < 0.05). Conclusions: Certain biomarkers were able to differentiate the clinical dengue cases. This could be potentially useful in classifying and determining the severity of dengue infected patients in the hospital. |
| Databáze: | OpenAIRE |
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