IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
| Autor: | Tetsuhiro Minamikawa, Yuki Ueda, Yukino Kawakatsu, Masatoshi Miyata, Shigehiro Motoi, Katsutoshi Yamaguchi, Misuzu Hitomi, Hideaki Kawabata, Daiki Sone, Yasuyuki Enoki, Yuji Okazaki, Naonori Inoue |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Male medicine.medical_specialty Cholagogues and Choleretics Nifedipine media_common.quotation_subject Prednisolone Anti-Inflammatory Agents Case Report Autoimmune hepatitis 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Japan Internal medicine Internal Medicine medicine Blood test Humans media_common Aged Hepatitis Chronic Hepatitis IgG4 Lymphocytic infiltration medicine.diagnostic_test autoimmune hepatitis business.industry Ursodeoxycholic Acid General Medicine medicine.disease Ursodeoxycholic acid drug-induced Hepatitis Autoimmune Treatment Outcome Immunoglobulin G Etiology Immunohistochemistry 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Needle liver biopsy specimen showed interface hepatitis with mainly lymphocytic infiltration and bridging fibrosis in the periportal area. Immunohistochemistry revealed lymphocytic infiltration positive for IgG4. We diagnosed him with IgG4-related AIH with an etiology that was suspected of being drug-induced. Oral prednisolone was started and then tapered after achieving biochemical remission. Hepatitis recurred after the cessation of steroids; however, remission was achieved with ursodeoxycholic acid. |
| Databáze: | OpenAIRE |
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