Severe Acute Respiratory Syndrome Coronavirus-2 Antibody Responses in Hospitalized Patients with Coronavirus Disease 2019 in Daegu, Korea
| Autor: | Yu Kyung Kim, Tae Yeob Kim, Eun-Hyung Yoo, Soo-Hyun Kim, Ji Yeon Ham, Mikyoung Park, Soon Hee Chang, Hyun Chul Lee, Do-Hoon Kim, Jung-Sook Ha, Dohsik Minn, Chang-Ho Jeon, Sunggyun Park, Nan Young Lee, Sang-Gyung Kim, Jae Hee Lee, Kyung Eun Song, Jang Soo Suh |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Hospitalized patients Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Enzyme-Linked Immunosorbent Assay Antibodies Viral Gastroenterology Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology Immunoglobulin G law.invention law Internal medicine Republic of Korea medicine Humans Respiratory system Polymerase chain reaction biology business.industry SARS-CoV-2 COVID-19 Antibody response Immunoglobulin M Antibody Formation biology.protein business |
| Zdroj: | Clinical laboratory. 67(11) |
| ISSN: | 1433-6510 |
| Popis: | Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started to spread in Daegu from the end of February 2020. IgG and IgM antibodies against SARS-CoV-2 were measured in hospitalized patients with COVID-19 with moderate to severe symptoms to improve the understanding of antibody responses.Methods: We enrolled 312 patients with COVID-19 admitted to seven hospitals located in Daegu. Using serum (or plasma) samples from patients with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infections, both IgG and IgM antibodies were measured using commercial enzyme-linked immunosorbent assay (R-FIND COVID-19 ELISA, SG medical, Seoul, Korea). Results: The median value from the initial diagnosis by confirming SARS-CoV-2 PCR to the sampling date was 24 days (day -1 to 88). The total positive rate of IgG was 93.9% and the positive IgM rate was 39.4%, without considering the elapsed period after diagnosis. Positive IgG and IgM rates were highest at 100.0% and 59.0% in 3 weeks (15–21 days), respectively. IgG showed a high positive rate of 79.3% even within 7 days after the initial diagnosis of the disease and maintained a positive rate of 97.8% until after 8 weeks. Conclusions: Among hospitalized patients with COVID-19, IgG was detected from the beginning of the diagnosis and persisted for an extended time period. |
| Databáze: | OpenAIRE |
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