miR-142 is a Sensitive Biomarker for the Diagnosis and Prognosis of Acute Myocardial Infarction
Autor: | Xiaodong Pan, Genshan Ma, Gaoliang Yan, Zhongpu Chen, Zulong Sheng |
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Rok vydání: | 2020 |
Předmět: |
Male
China 030213 general clinical medicine medicine.medical_specialty Myocardial Infarction Ischemia General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Creatine Kinase MB Form Humans cardiovascular diseases Myocardial infarction Correlation of Data Survival analysis biology business.industry Gene Expression Profiling Area under the curve Middle Aged Prognosis medicine.disease Survival Analysis Troponin Coronary arteries MicroRNAs Early Diagnosis medicine.anatomical_structure ROC Curve Area Under Curve biology.protein Cardiology Female Creatine kinase Myocardial infarction diagnosis business Biomarkers |
Zdroj: | Clinical Laboratory. 66 |
ISSN: | 1433-6510 |
Popis: | Background Acute myocardial infarction (AMI) is myocardial necrosis caused by acute and persistent ischemia and hypoxia of coronary arteries. AMI is one of the most common diseases in European countries and over 1.5 million AMI patients die of it in the United States annually. A collection of studies proposed that certain micro-RNAs play crucial roles in the onset and development of AMI. Methods Ninety-four AMI patients and 83 non-AMI healthy controls were recruited from Zhongda Hospital, Southeast University between July 2015 and September 2017. Serum samples were collected at admission and the expression of miR-142 was detected using real-time quantitative polymerase chain reaction (RT-qPCR) assays. Results miR-142 expression was markedly elevated in serum samples of AMI patients compared with the 83 non-AMI healthy controls. miR-142 expression was positively correlated with creatine kinase-KB (CK-MB; r = 0.6731, p = 0.0021) and troponin (r = 0.7138, p = 0.0013). The area under the curve (AUC) of miR-142, CK-MB, and troponin for the diagnosis of AMI were 0.9185, 0.8172, and 0.8717, respectively. Overall survival analysis implied that high miR-142 expression may predict poor survival (log-rank test, p = 0.0146). Conclusions miR-142 may be a diagnostic and prognostic indicator for AMI, and therefore, it may contribute to AMI clinicopathologic prediction. |
Databáze: | OpenAIRE |
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