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Rohovyi Yu. Ye., Ariychuk O. I., Gerush O. V. Pathophyisiology analysis overload nephron protein in the proximal tubule damage in the nephrolithiasis size stones of 0.6-1.0 sm. Journal of Education, Health and Sport. 2017;7(7):1325-1335. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1250508 http://ojs.ukw.edu.pl/index.php/johs/article/view/5515 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.07.2017. Revised: 02.07.2017. Accepted: 31.07.2017. UDК 616.633.962.4-02:616.613-003.7-089.879 PATHOPHYISIOLOGY ANALYSIS OVERLOAD NEPHRON PROTEIN IN THE PROXIMAL TUBULE DAMAGE IN THE Nephrolithiasis SIZE STONES OF 0.6-1.0 CM Yu. Ye. Rohovyi, O. I. Ariychuk, O. V. Gerush The higher state educational establishment of Ukraine “Bukovinian State Medical University”,Chernivtsi, Ukraine Abstract Nephrolithiasis as the most common urological disorder characterized by frequent early relapses, acquires a social character, because these patients are 30 to 45% of all urological patients, while in Europe the disease is diagnosed in 2% of the population. The study included 40 patients with nephrolithiasis, 10 patients constituted the control group. Set the “hidden” damage to the proximal nephron in the presence of renal stones with a size of 0.6-1.0 cm in the upper third of the ureter, the upper and middle sections of the calyx, which is confirmed by the inhibition of enzymatic fibrinolytic activity of urine, the presence of tubular proteinuria in the absence of inhibition of proximal reabsorption of sodium ions. The link “hidden” damage to the proximal tubule of the degree of overload of the proximal nephron is a protein graphics multicorrelation dependence between the protein concentration of urine, standardized excretion protein and excretion, which are becoming more significant disharmony form towards control in the following sequence: the upper third of the ureter, medium cup, top cup. Key words: nephrolithiasis, proteinuria, “latent damage of the proximal nephron”. |
