Data of ureagenesis from ammonia, glutamine and alanine, and mitochondrial aquaporin-8 expression in thioacetamide-treated hepatocytes
| Autor: | Raúl A. Marinelli, María de Luján Alvarez, Alejo M. Capiglioni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Glutamine
UREAGENESIS Mitochondrion Thioacetamide lcsh:Computer applications to medicine. Medical informatics ALANINE 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ammonia medicine lcsh:Science (General) 030304 developmental biology Alanine chemistry.chemical_classification 0303 health sciences AMMONIA MITOCHONDRIAL AQUAPORIN-8 Multidisciplinary Ureagenesis TAA thioacetamide Chemistry THIOACETAMIDE purl.org/becyt/ford/3.1 [https] Pharmacology Toxicology and Pharmaceutical Science Amino acid GLUTAMINE medicine.anatomical_structure mtAQP8 mitochondrial aquaporin-8 Biochemistry Urea cycle Hepatocyte Urea lcsh:R858-859.7 Mitochondrial aquaporin-8 purl.org/becyt/ford/3 [https] 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | Data in Brief Data in Brief, Vol 30, Iss, Pp 105632-(2020) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2352-3409 |
| Popis: | We present data about the synthesis of urea from different substrates, i.e., free ammonia, glutamine and alanine in primary cultured rat hepatocytes treated or untreated with the model hepatotoxic agent thioacetamide (TAA). We also provide data about the expression of mitochondrial aquaporin-8 (mtAQP8), a hepatocyte channel protein which facilitates ammonia diffusion into mitochondria to supply the urea cycle. Ammonia-derived ureagenesis was significantly inhibited by about 30% while that from the both amino acids resulted unaffected in TAA-treated hepatocytes. Protein expression of mtAQP8 was decreased by about 80% after TAA treatment. These data can be useful for the understanding of the mechanisms of drug-induced hepatic dysfunction. Fil: Capiglioni, Alejo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina |
| Databáze: | OpenAIRE |
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