Biomimetic Nanoarchitectonics of Hollow Mesoporous Copper Oxide-Based Nanozymes with Cascade Catalytic Reaction for Near Infrared-II Reinforced Photothermal-Catalytic Therapy

Autor:	Jun Wang, Jin Ye, Wubin Lv, Shuang Liu, Zhiyong Zhang, Jiating Xu, Miaojun Xu, Chunjian Zhao, Piaoping Yang, Yujie Fu
Rok vydání:	2022
Předmět:	Glucose Oxidase Biomimetics Photothermal Therapy Cell Line Tumor Neoplasms Tumor Microenvironment Humans Nanoparticles General Materials Science Hydrogen Peroxide Copper
Zdroj:	ACS Applied Materials & Interfaces. 14:40645-40658
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.2c11634
Popis:	Biomimetic nanozyme with natural enzyme-like activities has drawn extensive attention in cancer therapy, while its application was hindered by the limited catalytic efficacy in the complicated tumor microenvironment (TME). Herein, a hybrid biomimetic nanozyme combines polydopamine-decorated CuO with a natural enzyme of glucose oxidase (GOD), among which CuO is endowed with a high loading rate (47.1%) of GOD due to the elaborately designed hollow mesoporous structure that is constructed to maximize the cascade catalytic efficacy. In the TME, CuO could catalyze endogenous H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5710d1cdea2d73b67cd328d8fdfb722c https://doi.org/10.1021/acsami.2c11634 Zobrazit plný text záznamu