Functional Biomarkers for Amyotrophic Lateral Sclerosis
| Autor: | William Huynh, Thanuja Dharmadasa, Steve Vucic, Matthew C. Kiernan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
amyotrophic lateral sclerosis medicine.medical_specialty medicine.medical_treatment Treatment outcome lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Internal medicine transcranial magnetic stimulation Clinical heterogeneity medicine Amyotrophic lateral sclerosis lcsh:Neurology. Diseases of the nervous system 030304 developmental biology 0303 health sciences business.industry Disease progression cortical excitability medicine.disease neurophysiological biomarkers Transcranial magnetic stimulation Clinical trial Neurology Clinical diagnosis motor neuron disease Neurology (clinical) Lower motor neuron signs business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neurology, Vol 9 (2019) |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2018.01141 |
| Popis: | The clinical diagnosis of amyotrophic lateral sclerosis (ALS) relies on determination of progressive dysfunction of both cortical as well as spinal and bulbar motor neurons. However, the variable mix of upper and lower motor neuron signs result in the clinical heterogeneity of patients with ALS, resulting frequently in delay of diagnosis as well as difficulty in monitoring disease progression and treatment outcomes particularly in a clinical trial setting. As such, the present review provides an overview of recently developed novel non-invasive electrophysiological techniques that may serve as biomarkers to assess UMN and LMN dysfunction in ALS patients. |
| Databáze: | OpenAIRE |
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