Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
| Autor: | Mst. Ayesha Siddika, Takahiro Yamada, Risako Aoyama, Kumi Hidaka, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Chemistry (miscellaneous)
Organic Chemistry Drug Discovery ribonuclease P ribozyme RNA motif RNA nanostructure pre-tRNA processing Nucleic Acid Conformation RNA Molecular Medicine Pharmaceutical Science RNA Catalytic Physical and Theoretical Chemistry Microscopy Atomic Force Ribonuclease P Analytical Chemistry |
| Zdroj: | Molecules; Volume 27; Issue 23; Pages: 8298 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules27238298 |
| Popis: | Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization. The resulting RNA nanostructures can exhibit the catalytic function of the parent ribozyme in an assembly dependent manner. In this study, we designed and constructed open-form oligomers of a bimolecular form of an RNase P ribozyme. The ribozyme oligomers were analyzed biochemically and by atomic force microscopy (AFM). |
| Databáze: | OpenAIRE |
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