Germ cell transplantation: a review and progress report on ICSI from spermatozoa generated in xenogeneic testes
| Autor: | V. Tarlatzis, M. Schrader, D. Loutradis, Y. Mio, N. Kanakas, Nikolaos Sofikitis, H. Kawamura, Ikuo Miyagawa, J. Georgiou, D. Makredimas, E. Lolis, Y. Yamamoto, Apostolos Kaponis, X. Giannakopoulos, Dimitrios Giannakis |
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| Rok vydání: | 2003 |
| Předmět: |
Meiosis/physiology
Male endocrine system Cell Transplantation/methods Cell Transplantation Transplantation Heterologous Biology Cryopreservation Andrology Meiosis Testis medicine Animals Humans Sperm Injections Intracytoplasmic Fertility preservation Spermatozoa/cytology/*transplantation Spermatogenesis Mitosis Azoospermia Testis/*physiology Obstetrics and Gynecology Seminiferous Tubules medicine.disease Spermatozoa Tissue Donors Transplantation Kinetics medicine.anatomical_structure Seminiferous tubule Reproductive Medicine Spermatogenesis/physiology Germ cell |
| Zdroj: | Human Reproduction Update. 9:291-307 |
| ISSN: | 1460-2369 1355-4786 |
| DOI: | 10.1093/humupd/dmg015 |
| Popis: | Results from the transplantation of donor male germ cells into xenogeneic recipient seminiferous tubules indicate that donor spermatogonia are capable of differentiating to form spermatozoa morphologically characteristic of the donor species. Germ cell transplantation procedures combined with developments in freezing, culturing or enriching germ cell populations have applications of paramount importance in medicine, basic sciences and animal reproduction. Additionally, these techniques can serve as an alternative approach for gonadal protection and fertility preservation in patients with cancer. This article is a chronological critical review of the technological advances that followed the initial successful transplantation of mouse germ cells into recipient mice. Furthermore, the factors responsible for the immunological privilege properties of the testis and the parameters influencing the potential of mammalian germ cells to undergo mitosis and meiosis within a xenogeneic testis are described. Finally, the role of human germ cell transplantation procedures in the therapeutic management of non-obstructive azoospermia is discussed. Hum Reprod Update |
| Databáze: | OpenAIRE |
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